Public Title Isolation of Adenovirus E1 Expressing Cell Lines and Strategies to Generate Adenovirus Recombinants Division Lead Inventor Mittal, Suresh Public Description Following adenovirus infection of a cell, E1 genes are the first viral genes to be expressed and are essential for virus replication. Therefore, E1-deleted adenoviral vectors can only be generated and grown in a cell line that constitutively expresses E1 proteins. This technology involves the isolation of a number of cell lines expressing either human adenovirus (HAd) or bovine adenovirus (BAd) E1 genes. These isolated cell lines may be useful in generating and replicating adenovirus recombinants for vaccination and gene therapy applications. Patent Status Public References Key Words Biotechnology, Biotechnology/Cell lines, Biotechnology/Drug & biological delivery, Biotechnology/Gene & cell therapy Manager Matt McFarland Email mjmcfarland@prf.org Telephone 765-588-3487 Fax 765-463-3486   Back to List