Public Title Parallel Ion Parking in Ion Traps Division Lead Inventor McLuckey, Scott Public Description Electron transfer dissociaton (ETD) in a tandem mass spectrometer is an analytically useful ion/ion reaction technique for deriving polypeptide sequence information; however, its utility can be limited by sequential reactions of the products. Currently, the only method to influence the extent to which the sequential reactions occur is to stop the process before most of the parent ions have undergone any reaction. This technology is a process to minimize the formation of second generation fragment ions in electrodynamic ion traps when parent ions are undergoing a continuous form of ion activation that can also lead to fragmentation of first generation products. The approach can provide parent ions to first generation product ion efficiencies exceeding 90%. The result of this process is an improvement of the efficiency of a tandem mass spectrometry experiment resulting in lower detection limits and better sensitivity. Patent Status Public References Key Words Chemistry and Chemical Analysis, Chemistry and Chemical Analysis /Analytical methods, Chemistry and Chemical Analysis /Instrumentation Manager Karen White Email kfwhite@prf.org Telephone 765-588-3486 Fax 765-463-3486   Back to List