Public Title Design and Synthesis of New HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) Division Lead Inventor Cushman, Mark Public Description Researchers at Purdue have developed a series of non-nucleoside HIV-1 reverse transcriptase inhibitors of potential value for the treatment of AIDS. The compounds inhibit the cytopathic effect of HIV-1 at low nanomolar concentrations in cell culture. Some of the compounds have enhanced metabolic stabilities in rat blood plasma. Patent Status Public References Key Words anti-viral, HIV, HIV-1, non-nucleoside reverse transcriptase inhibitors, AIDS Manager Matt McFarland Email mjmcfarland@prf.org Telephone 765-588-3487 Fax 765-463-3486   Back to List