Public Title Adenoviral Vector-mediated Gene Therapy Approach for Breast Cancer and Development of an Immunocompetent Breast Cancer Mouse Model Division Lead Inventor Mittal, Suresh Public Description Various monoclonal antibody-based treatments for breast cancer exist at different stages of development. Present technologies utilize the nude mouse model of breast cancer, which is not a true reflection of what may occur in normal animals in response to these therapeutics. Purdue researchers found that, in breast cancer cells, the receptor tyrosine kinase EphA2 is over-expressed and, therefore, provides a unique target for breast cancer intervention. An immunocompetent mouse model of breast cancer has been developed for evaluating various therapeutic approaches including those involving activation or inhibition of EphA2. Patent Status Public References Key Words Biotechnology, Biotechnology/Gene & cell therapy, Biotechnology/Model systems Manager Matt McFarland Email mjmcfarland@prf.org Telephone 765-588-3487 Fax 765-463-3486   Back to List