Application Scientist

POSTED: March 18, 2022
BUSINESS: AsedaSciences
POSITION TYPE: Full-time
START DATE: Immediate Availability

Overview:

AsedaSciences performs cell-based phenotypic screening to determine the biological and physiological effects of small molecule compounds on defined cell types. The information generated is used to estimate risk of compound failure due to toxic effects, usually in the context of a pharmaceutical development pipeline. Planned future screens will inform mechanisms of action and provide means of lead compound discovery for cellular signaling pathways of specific therapeutic value.  Data generation is dependent on the capabilities of the company to perform cell-based screen protocols that include automated liquid handling and automated flow cytometry, as well as management of compound metadata and screening QC procedures.

Finally, and of critical importance, the AsedaSciences phenotypic screen design philosophy recognizes that development of analytical algorithms and physical screen protocols must be done in concert so that algorithm developers and cell-based screeners are aware of the informational needs of each other. This requires teamwork through iterative and transparent communication cycles that result in screening systems that provide reliable, repeatable, predictive information. Therefore, the ideal candidate for this Application Scientist role, while not needing to be a mathematician or programmer per se, must be willing to engage in algorithm-related conversations and apply logic, accumulated from solid bench experience, to the process of prototyping and implementing innovative cell-based screen designs.  As the hands-on person at the bench, the Application Scientist’s attention to detail and mindfulness of system design consequences are essential features of both current screen execution and efficient prototyping of new screen designs.

Responsibilities:

  • Perform current, validated cell-based screens using laboratory automation and flow cytometry instrumentation
  • Manage accurate migration of raw data from screening instruments to laboratory database, including support documentation according to AsedaSciences SOPs.
  • Contribute to the development and validation of biological assays and other laboratory procedures necessary for meeting GLP, customer expectations, and service contract requirements
  • Perform the necessary Quality Control tests to ensure the performance requirements of laboratory automation and flow cytometry platforms
  • Maintain screening-related equipment according to associated SOPs and organize and complete service and certification of said equipment to ensure function to specification.
  • Maintain accurate records of all equipment calibrations and user-performed maintenance required to meet manufacturer recommendations and GLP requirements
  • Troubleshoot and resolve aberrant screen results by determining root cause, providing a solution, and, where necessary, determining and implementing preventative measures
  • Periodically review scientific literature to understand best practices and critical requirements for the assays used by the Company

Minimum Requirements:

  • A Master’s degree with a minimum of 5 years related lab experience, or a Ph.D. (preferred) in cell biology or related field, with a minimum of three years related lab experience. Demonstration of skill/aptitude related to plate-based assays, laboratory automation, and cytometry instrumentation are required.
  • At least 2-3 years of demonstrated experience successfully implementing new cellular screening methods using automation processes
  • Extensive experience in running a cytometer, preferably flow cytometry, including instrument set-up and Q/C, protocol development, and validation, is highly desirable. Candidates with extensive experience of other forms of complex laboratory instrumentation and an ability to rapidly learn new systems by leveraging transferable concepts may also apply
  • Extensive direct, operational experience with laboratory automation, specifically liquid handling robots, is required. Ideal experience would include the development, implementation, and troubleshooting of automated assay protocols.
  • Strong (oral and written) communication and presentation skills. Refined interpersonal communication skills are a distinct advantage. History of success working with and contributing to a team-based laboratory facility that runs complex biological screening processes. Ability to rapidly articulate problems, insights and clear solutions is essential for collaborative problem-solving
  • Demonstrated history of contributing information for posters, publications, white papers and internal protocols or work instructions
  • Working knowledge of Good Laboratory Practice (GLP) requirements is highly desirable.
  • Knowledgeable and experienced in maintaining complex lab equipment.
  • Ability to work effectively and independently in a team environment
  • Ability to prepare reagents to stringent quality control requirements
  • Minimum of three references for validation of technical skills and experience
  • Excellent problem solving and troubleshooting skills
  • History of diligent laboratory record keeping in digital formats
  • Self-motivated and excited by opportunities to gain new skills and knowledge
  • Work history of excellent attendance and a track record of reliability and dependability
  • Ability and technical experience to handle toxic materials

 

Interested candidates can send a resume to careers@asedasciences.com 

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