Scientist 1, Radiochemist

POSTED: January 3, 2022
BUSINESS: Novosteo
POSITION TYPE: Full-time
START DATE: Immediate Availability

Job Summary:


Novosteo was founded to reduce the morbidity, mortality, and loss of productivity associated with bone fractures. Based on discoveries of agents that accelerate bone regeneration and breakthroughs in methods to target these agents selectively to fracture surfaces, Novosteo has designed a series of fracture-targeted drugs that concentrate a drug's healing power specifically at the fracture site, thereby greatly accelerating and improving the healing process. The mission of Novosteo is to reduce the debilitating and often life-threatening effects of bone fractures. This Job provides the exciting opportunity to be part of an innovative team contributing to the development and discovery of new pharmacological solutions for life threatening orthopedic diseases.


Responsibilities and duties:

  • Design, synthesize and evaluate novel targeted radiotherapeutics
  • Design, synthesize and evaluate novel radioisotope chelators
  • Design, synthesize and evaluate novel linkers
  • Design, synthesize and evaluate targeted small molecule therapeutics
  • Design, synthesize and evaluate novel radiotherapeutic payloads
  • Purify and characterize novel targeted radiotherapeutics
  • Analyze and characterize degradation patterns of radiotherapeutics
  • Optimize targeted radiotherapeutic drug to improve pharmacokinetics, safety window, and dosing
  • Characterize ADME metrics for targeted radiotherapeutics
  • Collaborate with biology team to evaluate novel targeted radiotherapeutics in in vivo models of bone cancer models
  • Responsible for NRC compliance
  • Experience working with positron emitting radionuclides, remote and automated systems
  • Performs daily radiation safety tasks, along with general lab cleaning
  • Responsible for maintaining and calibrating all equipment related to the development of radiotherapeutics

Skills and qualifications:

  • PhD in pharmaceutical science, organic chemistry, nuclear chemistry, medicinal chemistry, or other related field
  • 5 years lab experience
  • Working knowledge of applicable safety and standards guidelines, such as NRC regulations
  • Synthetic organic chemistry experience is required along with knowledge of related techniques
    including HPLC, MS, TLC, flash chromatography, NMR, and safe handling of chemicals and
    wastes
  • Experience with synthesis and production and quality control of radiopharmaceuticals
  • Experience with chemical synthesis and organic chemistry analysis methods
  • Must be able to lift 60 lbs
  • Must be willing to work with radioisotopes
  • Must have the ability to handle multiple tasks simultaneously and to work in high-pressure
    situations
  • Demonstrated track record for troubleshooting chemical reaction and processes
  • Robust publication track record
  • Experience working with radiochemistry, and formulation
  • Experience with ADME optimization
  • Analytical skills for conducting scientific experiments
  • Communication skills for writing and publishing research papers and reports, giving
    presentations and communicating with team members
  • Critical-thinking skills for drawing conclusions from experimental results through sound
    judgment and reasoning
  • Interpersonal skills for working well with others on a team towards a common goal
  • Perseverance to be thorough in their approach to problems and in their research
  • Problem-solving skills when using analysis and scientific experiments to identify solutions to
    complex scientific problems
  • Time-management skills for meeting deadlines when conducting research and prioritizing tasks

 

To apply for this position, please submit CV to careers@novosteo.com. 



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